Epigastric pain is a hallmark symptom of functional dyspepsia (FD), often challenging to manage when resistant to standard treatments. We present the case of a 46-year-old woman with persistent epigastric pain meeting Rome IV criteria for FD, unresponsive to Helicobacter pylori eradication, proton pump inhibitor, and a herbal medicine, Rikkunshito. The patient’s symptoms were exacerbated by psychosocial stressors, including a traumatic family history of gastric cancer and unresolved emotional distress. A narrative-based, psychosomatic approach was introduced, integrating elements of cognitive behavioral therapy and whole person care. The physician guided the patient to observe her thoughts, bodily sensations, and emotional responses, fostering self-awareness and emotional regulation. Over 6 months, her symptoms improved, and she was discharged. This case illustrates that treatment-resistant FD may require interventions beyond pharmacological therapy, addressing the patient’s cognition and emotion. A strong physician–patient relationship and attentiveness to psychosocial context are vital. Whole person care, involving both problem-solving and narrative modes, can help physicians maintain therapeutic presence under clinical stress. This approach enhances patient-centered care and supports symptom management, even when complete resolution is not possible.