The Western Pacific Region faces significant disparities in health workforce distribution, with some countries falling well below the Sustainable Development Goal threshold of 4.45 skilled health workers per 1000 population. Rapid population ageing and the increasing burden of noncommunicable diseases further exacerbate shortages, particularly in rural and underserved areas. Task shifting—the redistribution of healthcare responsibilities from physicians to nurses, pharmacists, and community health workers—has been promoted by the World Health Organization as an effective strategy to expand access, improve efficiency, and maintain the quality of care. Evidence demonstrates its effectiveness in areas such as HIV/AIDS, tuberculosis, maternal care, and chronic disease management, provided adequate training, supervision, and supportive organizational structures are ensured. However, challenges remain, including risks to patient safety, professional resistance, role ambiguity, and workforce burnout. Interprofessional education (IPE) plays a crucial role in addressing these challenges, as it promotes collaboration, role clarity, and mutual respect among healthcare professionals. Longitudinal and practice-based IPE programs, such as those developed at Gunma University, have shown effectiveness in strengthening professional identity, improving patient safety, and sustaining interprofessional collaboration. To address workforce gaps in the Western Pacific Region, it is essential to integrate IPE into curricula and national policies, tailor programs to local contexts, and promote regional and international cooperation. The synergy of task shifting and IPE offers a transformative pathway to strengthen health systems, ensure equitable service delivery, and enhance the quality of care across the region.