The Alpine biome is home to a diverse array of medicinal herbs with noteworthy biological, ethnobotanical, and medicinal importance. The uniqueness of alpine biome medicinal herbs is attributed to their higher altitude, shorter growth periods, and low temperatures. With the intensification of the changing climatic conditions, the alpine zone ecosystem is experiencing increasing annual temperatures, fluctuating rainfall dynamics, melting glaciers and elevated occurrence of severe weather events. These climatic changes endanger the existence, distribution and metabolic makeup of alpine flora in the Himalayan region. This chapter highlights the climate-induced stress impact on the growth dynamics, habitat and plant diversity destruction resulting in elevation shifts for the distribution of important alpine flora, also providing an outline of floral biodiversity in the alpine zone of the Himalayas, emphasizing their survival characteristics, niche functions and involvement in indigenous health systems, specifically in alpine regions. Major focus is on the biological potential of these plants, where majority of them act as ecological markers and are important in village-based livelihoods via indigenous medicinal utilisation and trade. They are vital element of alpine habitats, and their unique characteristics acts as a foundation for understanding climate impact-related processes. Rising temperatures allow lower-altitude species to infiltrate alpine ecosystems, increase the competition and potentially replacing native flora and fauna. Conservation measures are critical for conserving alpine biodiversity despite these challenges.