Current methods for the synchronous and real-time monitoring of cerebral blood flow (CBF) and cerebral blood oxygenation (CBO) under high-altitude hypoxic conditions remain limited. This study presents a noninvasive approach that combines near-field coupling and near-infrared spectroscopy (NIRS) technologies to synchronously monitor CBF and CBO, aiming to assess cerebral metabolism and hemodynamic changes in high-altitude hypoxic environments. Data were collected from 24 lowland volunteers and 80 long-term residents living at 3,500 m above sea level. The proposed method measures cerebral hemodynamic parameters—cycle area (S) and cycle amplitude (A)—and regional cerebral oxygen saturation (rSO₂). Transcranial Doppler (TCD) parameters, peripheral oxygen saturation (SpO₂), and heart rate (HR) were used as reference indicators. Results showed no significant difference in rSO₂ between the two groups; however, the near-field coupling parameters S and A differed significantly, suggesting that low-pressure hypoxia may activate regulatory mechanisms in small arterioles to maintain CBF and CBO supply homeostasis. The findings demonstrate that the proposed method enables noninvasive and dynamic monitoring of CBF and CBO under hypoxic conditions, offering a more comprehensive evaluation of cerebral metabolic and hemodynamic alterations compared to conventional approaches.