Cold atmospheric plasma (CAP) has bright prospects in the field of clinical medicine, particularly for tumor therapy and wound repair, owing to abundant reactive oxygen and nitrogen species produced during discharges. Previous studies have shown multiple biological effects of CAPs including broad-spectrum disinfection, inflammation regulation, angiogenesis promotion, stimulation of cellular proliferation and migration, etc. In this study, a multi-mode CAP wound therapy system is designed, which integrates a surface dielectric barrier discharge (SDBD) module and a plasma-activated liquid (PAL) generation module onto a vacuum sealed drainage (VSD) dressing-based platform. Preliminary in vitro experiments are also conducted based on this multi-mode CAP wound therapy system. The proliferation of human immortalized keratinocytes (HaCaT cells) after plasma treatment is assessed using a CCK-8 assay, while the plasma induced enhancement of HaCaT cell migration is tested via a scratch assay. This research is helpful for subsequent in vivo animal experiments in order to further investigate the biological effects of the multi-mode CAP wound therapy system in future research.