3D printing is a technique that uses a layer-by-layer construction process for manufacturing different objects from various materials, following the design presented by a computer-aided model. The integration of additive manufacturing, more commonly known as 3D printing, into surgical practice has opened transformative possibilities in the design, fabrication, and deployment of surgical instruments. Also known as additive manufacturing, this technique has emerged as an important technology for producing mass-customized objects and has found its way into agriculture, healthcare, and the automotive industry. In medical surgeries, this technology has been used to manufacture various customized surgical instruments depending on the patient’s specific physiology and the surgeon’s individuality. In surgeries like minimally invasive surgeries and robot-assisted surgeries, this technology has paved the way for the manufacturing of futuristic, customizable tools within a few hours. This chapter explores the emergence and clinical application of 3D-printed surgical tools, with a focused examination of their advantages in customization, cost-effectiveness, and sterilization compatibility—three pivotal factors influencing surgical innovation and healthcare delivery. Furthermore, the chapter addresses critical barriers to adoption, including regulatory uncertainty, sterilization challenges, and the ethical implications of point-of-care manufacturing. It also highlights emerging trends such as surgeon-driven design, hospital-based fabrication labs, and the incorporation of artificial intelligence (AI) for automated tool customization based on preoperative imaging.