The need for flexible and high-performing antenna materials has increased as wireless communication systems develop into more integrated, small, and flexible platforms—particularly with the global rollout of 5G infrastructure and the explosive growth of IoT devices. Due to its inherent ferroelectric characteristics and superior dielectric qualities, polyvinylidene fluoride (PVDF), a semi-crystalline fluoropolymer, has become a popular substrate for flexible antennas. The dielectric stability of PVDF, which has a relative permittivity ranging from 8 to 12 and a consistently low loss tangent (<0.02) over a broad frequency spectrum relevant to RF applications, is examined in this chapter. Furthermore, ferroelectric modulation of antenna performance metrics such as beam steering, bandwidth, and impedance is made easier by its reversible spontaneous polarization in the β-phase. A thorough analysis is conducted of the design of PVDF-based conformal antennas, their construction on curved and deformable substrates, and their integration with 5G and IoT modules. Applications include biomedical telemetry, wearable electronics, smart textiles, and mobile 5G devices—fields where mechanical flexibility and dielectric integrity are critical. PVDF’s role in adaptive frequency-selective antennas and reconfigurable intelligent surfaces (RIS), supported by its potent ferroelectric switching capabilities, are examples of emerging applications. PVDF offers a ground-breaking method for flexible, conformal, and reconfigurable antenna designs in upcoming wireless networks by combining ferroelectric tunability and dielectric efficiency. In recent years, advancements in additive manufacturing and printable electronics have further accelerated the deployment of PVDF-based antennas across diverse platforms. Techniques such as inkjet printing, screen printing, and fused filament fabrication (FFF) have enabled high-resolution patterning of conductive elements on PVDF films, allowing for scalable and cost-effective antenna prototyping. Moreover, hybrid integration of PVDF with nanofillers like BaTiO₃, graphene, and MXenes has opened new pathways for tunable permittivity and enhanced RF functionality. These composite formulations can be engineered to optimize performance across multiband and ultrawideband (UWB) regimes, making them ideal candidates for cognitive radio, vehicular networks, and next gen mm Wave communications. The convergence of material science, smart manufacturing, and reconfigurable RF design solidifies PVDF’s position as a cornerstone material for future wireless antenna systems. Additionally, PVDF’s application in conformal antenna design also promotes the creation of body-worn and implantable antennas, where biocompatibility and mechanical compliance are vital. Unlike rigid substrates, which often fall short of performance, surface-mounted PVDF-based antennas can preserve consistent radiation properties despite stretching, bending, or folding. Moreover, the anisotropic permittivity and polarization behavior of PVDF enable designers to dynamically control the propagation of electromagnetic waves, therefore providing possibilities for real-time beam reconfigurability and directional radiation patterns in MIMO and beamforming arrays. Research has looked at field-induced tunability in PVDF-based metasurfaces and frequency-selective surfaces (FSS) to enable smart RF environments responding to electrical bias or environmental stimuli, therefore maximizing its ferroelectric behaviour. All vital in crowded spectrum situations like urban 5G cells and dense IoT deployments, this allows dynamic impedance matching, programmable frequency hopping, and environment-adaptive antenna performance. Improvements in 3D-printed dielectric structures using PVDF blends also indicate potential in designing volumetric antennas with maximum gain and reduced side lobes. Finally, PVDF’s use in ultra-conformal platforms like epidermal electronics and implantable devices is enhanced by its combination with stretchable interconnects and soft encapsulation layers. PVDF naturally supports these new systems’ need for high RF efficiency with low signal distortion even under biomechanical stress. The adaptability of PVDF improved by chemical changes, composite engineering, and microstructural alignment will help to shape the next frontier of flexible, smart, and high-frequency antenna systems as wireless standards evolve toward 6G, terahertz (THz) applications, and intelligent reflecting surfaces (IRS).