Antimicrobial resistance (AMR) has emerged as one of the most urgent global health threats, primarily driven by the overuse and misuse of antibiotics and environmental contamination through water, soil, and food. These factors create an environment where resistant pathogens proliferate, facilitated by transferring resistance genes through both vertical and horizontal transmission. This results in the rapid emergence and spread of multidrug-resistant (MDR) bacteria, which are increasingly difficult to treat with conventional antibiotics. In response to this escalating crisis, innovative solutions are urgently needed, and one such promising approach lies in the use of nanoparticles (NPs). NPs offer a promising solution to combat AMR by enhancing drug delivery and disrupting bacterial cell walls, biofilms, and intracellular components. While concerns about toxicity and biocompatibility exist, plant-based NPs may offer a safer alternative. Recent advances in nanoscience and machine learning may further improve the design and effectiveness of NPs, making them more efficient for targeted treatments and contributing to innovative solutions for tackling AMR.