Zoonoses, the diseases transmitted between animals and humans, pose a significant global health concern. This chapter travels the assorted realm of zoonotic diseases, probing into their multifaceted classifications based on pathogen type, transmission modes, and ecological characteristics. The chapter strains on the major categories of zoonotic pathogens, including viruses, bacteria, parasites, and fungi, and provides examples of prominent diseases within each group. Furthermore, the chapter digs into the various transmission pathways, including direct contact, vector-borne transmission, foodborne transmission, and environmental exposure, highlighting the complexities inherent in zoonotic spillover events.