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Animal models are key to obtaining insights into disease mechanisms and developing prophylactic and treatment measures. We have recently developed a rat model of BRCA1 deficiency and revealed that this model mimics many of the phenotypes in humans. Herein, we briefly review the development and characterization of the phenotypes of this model.

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Knock-In Rat Model of the BRCA1 Pathogenic Variant p.L63X: Its Basic Phenotypes and Perspectives for Use in Cancer Prevention Research

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  • 发表日期：

    2026年

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  • Tatsuhiko Imaoka,
  • Yuzuki Nakamura,
  • Kento Nagata,
  • Yukiko Nishimura-Yano,
  • Kazuhiro Daino,
  • Atsuko Ishikawa

摘要

Animal models are key to obtaining insights into disease mechanisms and developing prophylactic and treatment measures. We have recently developed a rat model of BRCA1 deficiency and revealed that this model mimics many of the phenotypes in humans. Herein, we briefly review the development and characterization of the phenotypes of this model.