This chapter explores the evolution, frameworks, and practical implications of the food–energy–water (FEW) nexus in the context of sustainable urban development. It synthesizes recent advances in nexus assessment, modeling, governance, design, and policy integration. By examining multiple analytical approaches—including input–output analysis, life cycle assessment, and participatory modeling—the author highlights the strengths and limitations of current methods, particularly their often-fragmented treatment of cross-sectoral dynamics and lack of spatial resolution. The role of governance is emphasized through stakeholder engagement and codesign processes that support system understanding and decision-making. Conceptually, the FEW nexus is advanced through boundary objects such as urban metabolism and traits frameworks, which help translate complex interdependencies across disciplines and scales. Entry points—such as food systems, water management, or urbanization—are critical for operationalizing the nexus in place-based contexts. Key themes discussed include the need for transdisciplinary integration, improved data infrastructure, and adaptive governance structures. The chapter argues that embedding the nexus in urban planning and policy can unlock synergistic solutions that enhance resource efficiency, resilience, and equity. The findings offer a roadmap for moving beyond sectoral silos toward a more integrated, systemic approach to sustainability in the Anthropocene.