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Polydopamine (PDA)-coated Fe3O4/SiO2 nanoparticles (Fe3O4@PDA@SiO2) were synthesized through a simple procedure. Fe3O4@PDA@SiO2 showcasing exceptional stability, biocompatibility, and impressive magnetothermal properties under alternating magnetic fields (AMF). These nanoparticles effectively generate localized heat, leading to the successful ablation of liver cancer cell (SNU423 cells). The results underscore the significant magnetothermal efficacy of Fe3O4@PDA@SiO2 against cancer cells. Furthermore, cytotoxicity assays demonstrate that at a concentration of 50 μg/mL, these nanoparticles do not adversely affect cell viability. In conclusion, biocompatible Fe3O4@PDA@SiO2 nanoparticles offer a promising approach for cancer treatment through magnetic hyperthermia therapy.

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Synthesis of Biocompatible Iron Oxide Nanoparticles for Magnetic Hyperthermia Therapy of Liver Cancer

  • 会议论文

  • 发表日期：

    2026年

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  • Linxue Zhang,
  • Qifan Li,
  • Chuanjian Wu,
  • Xiaona Jiang,
  • Zhongwen Lan,
  • Zhong Yu,
  • Ke Sun

摘要

Polydopamine (PDA)-coated Fe3O4/SiO2 nanoparticles (Fe3O4@PDA@SiO2) were synthesized through a simple procedure. Fe3O4@PDA@SiO2 showcasing exceptional stability, biocompatibility, and impressive magnetothermal properties under alternating magnetic fields (AMF). These nanoparticles effectively generate localized heat, leading to the successful ablation of liver cancer cell (SNU423 cells). The results underscore the significant magnetothermal efficacy of Fe3O4@PDA@SiO2 against cancer cells. Furthermore, cytotoxicity assays demonstrate that at a concentration of 50 μg/mL, these nanoparticles do not adversely affect cell viability. In conclusion, biocompatible Fe3O4@PDA@SiO2 nanoparticles offer a promising approach for cancer treatment through magnetic hyperthermia therapy.