The global drive towards sustainable agriculture has intensified interest in organic nutrient sources that enhance soil fertility and plant productivity without compromising environmental integrity. Vermicomposting, the bioconversion of organic waste through earthworms and microorganisms, produces not only nutrient-rich vermicompost but also vermi-leachates,liquid by-products that contain a complex mixture of soluble nutrients, phytohormones, beneficial microorganisms, and bioactive compounds. This chapter explores the production, composition, and applications of vermi-leachates, emphasizing their role as biofertilizers and plant growth promoters in horticultural systems. It highlights their ecological and agronomic benefits, including improved soil structure, increased microbial activity, enhanced nutrient cycling, and greater resistance to pests and abiotic stresses. Additionally, this chapter evaluates the economic feasibility and market potential of vermi-leachates, considering both their comparative advantages over synthetic fertilizers and the challenges associated with organic certification, scalability, and cost. By presenting a comprehensive overview, this chapter advocates for the integration of vermi-leachates into regenerative and climate-resilient agricultural practices aimed at achieving long-term food security and environmental sustainability.