Double-row tapered roller bearings are widely used in electric power, high-speed rail, automobiles, and airplanes. This chapter takes a double-row tapered roller bearing as the research object. Based on the Workbench platform of ANSYS, the FE model of a double-row tapered roller bearing under different constraints and loads is established, and the distribution law of equivalent stress and equivalent strain of the tapered roller bearing under different interference magnitudes between roller and inner and outer raceway is studied. The results show that: with the increase of interference magnitude between roller and raceway of inner and outer rings, the maximum equivalent stress and strain of the double-row tapered roller bearing first decrease and then gradually increase, and when the interference magnitude is 0.003 mm, the maximum equivalent stress and strain reach the minimum value. Therefore, when there is a certain amount of interference magnitude between roller and raceway of inner and outer rings, the equivalent stress and strain of the bearing can be reduced, and when the interference magnitude is 0.003 mm, the equivalent stress and strain of the bearing can be significantly reduced.