Background: The shoulder complex plays a key role in skilled throwing motions, common in sports like baseball, handball, and cricket. The thrower’s 10 exercise program, developed by Wilk et al. in 1991 based on EMG studies, aims to enhance the strength, power and endurance of shoulder muscles. This program has shown effectiveness in rehabiliting and preventing injuries in overhead athletes, with exercises tailored specifically to throwers. This study aims to identify if the throwers’s 10 exercise program effectively improves shouder performance.Aim: The aim is to analyze the effect of Throwers ten program and plyometric training in overhead athletes using quantitative analysis facilitated by SPSS.Methods: A total of 40 male athletes were chosen between the age groups of 18 and 25 and randomly allocated to Throwers ten group and plyometric training group respectively. Shoulder strength and performance of the athletes is measured using Seated Medicine Ball Throw test(SMBT) and Closed Kinetic Chain Upper Extremity Stability Test(CKCUEST). Participants in Throwers ten group were trained for throwers ten program for a period of 8 weeks, Plyometric group participant were trained for plyometric training for 8 weeks.Result: Throwers ten program showed substantial difference in improving the shoulder performance when compared to plyometric training. Post test values of throwers ten program in SMBT and CKCUEST had a significant difference, where the p value was <0.001.Conclusion: Throwers ten program is found to be more effective than plyometric training in improving the shoulder performance and emphasizes its role in promoting inclusive health among overhead athletes.