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Marine-derived natural products (MNPs) have long been undermined as potential resources for neurodegenerative disease intervention, offering preventive and therapeutic implications through versatile bioactivities. In this systematic review, the exploration of MNPs’ chemical features and mechanistic actions will aid in addressing the pathological hallmarks of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. Unique compounds, such as 11-dehydrosinulariolide, bryostatin-1, and dieckol, exhibit neuroprotective capabilities through the mitigation of oxidative stress, neuroinflammation, mitochondrial dysfunction, and protein aggregation. Additionally, various marine bioactives demonstrate significant efficacy in both in vitro and in vivo models, engaging essential molecular pathways such as the PI3K/Akt, Nrf2/ARE, MAPK, and gut-brain axis pathways. Emerging research suggests that many of these natural compounds could potentially play roles in epigenetic modulation and synaptic restoration, pioneering the opportunity for precision medicine, specifically tailored interventions. Overall, this review highlights the transformative potential of MNPs while emphasizing the importance of interdisciplinary collaboration to accelerate clinical breakthroughs. As the ocean continues to yield molecular insights, MNPs offer a compelling avenue toward novel neurotherapeutics in an era of aging populations and escalating neurological burdens.

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Modern Scope, Outcomes, and Potential Application of Marine-Derived Natural Bioactives to Advance the Field of Neuroscience

  • 章节

  • 发表日期：

    2026年

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  • Carson Greer,
  • Keyi Liu,
  • Preston Cook,
  • Suhrud Pathak,
  • Rishi Nadar,
  • Muralikrishnan Dhanasekaran,
  • Nishi Ann,
  • Jaufar Palekkodan,
  • Husni Ahmed Abdullah Al-Goshae,
  • Vijeyrani Vadipatti Baskarpandian

摘要

Marine-derived natural products (MNPs) have long been undermined as potential resources for neurodegenerative disease intervention, offering preventive and therapeutic implications through versatile bioactivities. In this systematic review, the exploration of MNPs’ chemical features and mechanistic actions will aid in addressing the pathological hallmarks of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. Unique compounds, such as 11-dehydrosinulariolide, bryostatin-1, and dieckol, exhibit neuroprotective capabilities through the mitigation of oxidative stress, neuroinflammation, mitochondrial dysfunction, and protein aggregation. Additionally, various marine bioactives demonstrate significant efficacy in both in vitro and in vivo models, engaging essential molecular pathways such as the PI3K/Akt, Nrf2/ARE, MAPK, and gut-brain axis pathways. Emerging research suggests that many of these natural compounds could potentially play roles in epigenetic modulation and synaptic restoration, pioneering the opportunity for precision medicine, specifically tailored interventions. Overall, this review highlights the transformative potential of MNPs while emphasizing the importance of interdisciplinary collaboration to accelerate clinical breakthroughs. As the ocean continues to yield molecular insights, MNPs offer a compelling avenue toward novel neurotherapeutics in an era of aging populations and escalating neurological burdens.