Hazardous environmental contaminants, both naturally occurring and anthropogenically introduced, present significant ecological challenges. These pollutants include a wide range of chemical classes, such as polycyclic aromatic hydrocarbons (PAHs), dyes, detergents, plastics, dioxins, pharmaceuticals, and complex mixtures, like creosote and oil. A major concern arises when pollutants enter ecosystems through leaks or accidental discharges, overwhelming the natural microbial communities and hindering effective biodegradation. Unlike organic pollutants, metals are persistent, remaining in the environment for thousands of years due to their inability to be degraded. Although they undergo oxidation or complexation, they still accumulate in soil and water, posing long-term ecological and health risks. Bio-sorption, a process where microorganisms remove metals from aqueous environments, plays a vital role in remediation efforts. Myco-sorption, or fungal-mediated bio-sorption, has attracted considerable global interest owing to fungi’s structural and biochemical versatility. Their expansive mycelial networks, nonspecific catabolic enzymes, and cell walls enriched with functional groups, such as amino, hydroxyl, carboxyl, and phosphate, allow them to bind and immobilize metals, metalloids, and radionuclides efficiently. Mycoremediation, the application of fungi for ecosystem restoration, is an emerging, sustainable strategy. Ongoing research explores fungal species, degradation pathways, and innovations like myco-nanotechnology to enhance remediation efficiency, offering promising solutions for polluted environments.