With the advancement of artificial intelligent (AI) technologies, intelligent agents have begun to demonstrate capabilities such as situational awareness, user intent recognition, and autonomous learning. This evolution has led to the emergence of a new interaction form known as Human-AI Interaction (HAII)Human-AI Interaction (HAI). The novel characteristics of HAII—such as adaptability, collaboration, bidirectionality, and proactivity—present new challenges to traditional Human–Computer Interaction (HCI). As a result, existing interaction models and design paradigms within HCI face challenges in effectively supporting the advancement of HAII. Therefore, to transcend traditional interaction models and design paradigms and provide users with superior experiences, it is essential to develop effective interaction models and design paradigms that guide the creation of robust interaction frameworks, supporting the design and development of human-centered AI systems. This chapter provides an overview of interaction and design paradigms in traditional HCI. It then explores emerging interaction models and design paradigms for HAII, offering valuable references and insights for future research.