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The Fukushima Daiichi Nuclear Power Plant (FNPP) accident has sparked health-related concerns, since a certain amount of radioactive material was released into the environment. To determine the impact of radioactive contamination, many studies have investigated its effects on livestock and wild animals in the ex-evacuation zone. This study aimed to evaluate oxidative DNA damage caused by long-term exposure to low-dose-rate radiation attributed to the FNPP accident by analyzing 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in the liver, kidney, and skeletal muscle DNA of cattle in the evacuation zone using a high-performance liquid chromatography–electrochemical detector. The results showed that 8-OHdG levels in the liver and kidney tended to increase in a dose-rate-dependent manner. Further investigation of the mechanism of oxidative DNA damage induced by low-dose-rate irradiation, including organ specificity, is warranted. To our knowledge, this is the first study to evaluate the impact of radioactive contamination by the FNPP accident using 8-OHdG, the most common oxidative DNA damage marker.

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Assessment of Oxidative DNA Damage in the Affected Cattle After the Fukushima Daiichi Nuclear Power Plant Accident

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  • 出版模式：

    开放获取

  • 发表日期：

    2026年

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  • Kazuaki Kawai,
  • Koichi Fujisawa,
  • Yuko Ootsuyama,
  • Masatoshi Suzuki,
  • Yun-Shan Li,
  • Manabu Fukumoto,
  • Hiroshi Kasai

摘要

The Fukushima Daiichi Nuclear Power Plant (FNPP) accident has sparked health-related concerns, since a certain amount of radioactive material was released into the environment. To determine the impact of radioactive contamination, many studies have investigated its effects on livestock and wild animals in the ex-evacuation zone. This study aimed to evaluate oxidative DNA damage caused by long-term exposure to low-dose-rate radiation attributed to the FNPP accident by analyzing 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in the liver, kidney, and skeletal muscle DNA of cattle in the evacuation zone using a high-performance liquid chromatography–electrochemical detector. The results showed that 8-OHdG levels in the liver and kidney tended to increase in a dose-rate-dependent manner. Further investigation of the mechanism of oxidative DNA damage induced by low-dose-rate irradiation, including organ specificity, is warranted. To our knowledge, this is the first study to evaluate the impact of radioactive contamination by the FNPP accident using 8-OHdG, the most common oxidative DNA damage marker.