Nanomaterial composites can be employed not only as contrast agents for diagnostic biomedical imaging but also as integral components of biosensing devices that detect biomarkers in minimally invasive fluids such as blood. This chapter explores the different methods for nanocomposite fabrication and characterization, along with advancements made in the context of biomedicine. Materials incorporated into nanocomposites, along with their key properties enabling medical diagnostics, are discussed. Recent advancements include but are not limited to the development of superparamagnetic iron oxide nanoparticles for biomedical imaging, as well as gold nanoparticle composites for liquid biopsy and theranostics. Despite these advancements, there are still challenges for clinical translation. Future studies should prioritize thorough nanomaterial characterization, standardization of methods for analysis, development of multifunctional platforms, and clinical trials to validate performance. Overall, this chapter aims to promote ongoing discussion within the nanomedicine domain and encourage continued exploration as well as innovative solutions.

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Advances in Nanocomposites and Their Applications in Medical Diagnostics

  • Mark Woollam,
  • Eray Schulz,
  • Yeshwant Kasa,
  • Akanksha Tipparti,
  • Shivaum Heranjal,
  • Akshay Mane,
  • Mangilal Agarwal

摘要

Nanomaterial composites can be employed not only as contrast agents for diagnostic biomedical imaging but also as integral components of biosensing devices that detect biomarkers in minimally invasive fluids such as blood. This chapter explores the different methods for nanocomposite fabrication and characterization, along with advancements made in the context of biomedicine. Materials incorporated into nanocomposites, along with their key properties enabling medical diagnostics, are discussed. Recent advancements include but are not limited to the development of superparamagnetic iron oxide nanoparticles for biomedical imaging, as well as gold nanoparticle composites for liquid biopsy and theranostics. Despite these advancements, there are still challenges for clinical translation. Future studies should prioritize thorough nanomaterial characterization, standardization of methods for analysis, development of multifunctional platforms, and clinical trials to validate performance. Overall, this chapter aims to promote ongoing discussion within the nanomedicine domain and encourage continued exploration as well as innovative solutions.