This chapter investigates the integration of renewable energy systems within transportation infrastructures, leveraging principles derived from the human immune system. It addresses the critical challenge of “tolerable time gaps” between energy generation and consumption, particularly with intermittent renewable sources such as solar and wind. Drawing upon key immune system concepts—such as adaptive immunity, cytokine signaling, and feedback loops—the chapter introduces a novel framework for managing and controlling multi-source renewable energy in the context of an integrated transport–energy system. It emphasizes the real-time coordination of energy sources (e.g., solar, wind, and batteries) with energy consumption demands, such as electric vehicle charging, to ensure optimal distribution and efficiency. Furthermore, the chapter explores the application of immune-inspired models to optimize energy flow, mitigate uncertainties, and bolster system resilience. Ultimately, it demonstrates how immune-based approaches can provide innovative solutions for enhancing the sustainability, flexibility, and adaptability of transport–energy integration.