Endoscopic Fundoplication for Gastroesophageal Reflux Disease
摘要
Proton pump inhibitors (PPIs) are currently the main drugs for treating gastroesophageal reflux disease (GERD). Due to the limitation of its therapeutic effect, 17%–32% of patients still have reflux symptoms after taking PPIs, some patients need long-term or even life-long medication, and about 75%–90% of patients show reflux symptoms after withdrawing [1]. Although laparoscopic fundoplication can relieve recurrent reflux symptoms, less than 5% of patients have received laparoscopic fundoplication due to the massive surgical trauma and higher surgical indications compared with endoscopy [2]. As a result, about 25%–30% of GERD patients have poor curative effects after taking drugs or cannot tolerate long-term medication but are unwilling to carry out surgical treatment. The emergence of gastroesophageal reflux endoscopic treatment technology is filling this gap [3–5].