Scholarlink

The immunological functions of glycans were investigated using well-defined synthetic glycans, with the aim of enabling precise immune modulation. Efficient methods for glycan synthesis were established, enabling identification of structural determinants of immunological activity with structurally defined synthetic glycans. Immune modulation was achieved using bioactive glycans and inhibitors of glycan biosynthetic enzymes. Furthermore, aspects of the emergent functions of glycans were elucidated by employing glycan conjugates, including self-adjuvanting vaccine constructs.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Elucidating the Immune Functions of Glycans Through Synthesis-Based Approaches

  • 章节

  • 发表日期：

    2026年

查看全文
  • Koichi Fukase,
  • Atsushi Shimoyama,
  • Yoshiyuki Manabe

摘要

The immunological functions of glycans were investigated using well-defined synthetic glycans, with the aim of enabling precise immune modulation. Efficient methods for glycan synthesis were established, enabling identification of structural determinants of immunological activity with structurally defined synthetic glycans. Immune modulation was achieved using bioactive glycans and inhibitors of glycan biosynthetic enzymes. Furthermore, aspects of the emergent functions of glycans were elucidated by employing glycan conjugates, including self-adjuvanting vaccine constructs.