Interdisciplinary practical activities for junior secondary chemistry that integrate computational thinking were introduced into regular teaching, combining chemistry, information technology, mathematics, biology, and other disciplines. The instructional design of a life-production spiral was adopted, and the interdisciplinary practical activities were conducted collaboratively in small groups, focusing on the evaluation and enhancement of design solutions. The selection of gastric pills and the industrial production process were initially addressed using programmed digital equipment. This practical activity enables students to analyze and solve problems from various perspectives, fostering knowledge acquisition through inquiry, enhancing motivation and attitudes towards learning, and cultivating essential 21st-century interdisciplinary competencies such as critical thinking, innovative thinking, problem-solving skills, and communication and collaboration abilities. Additionally, it enriches and improves the teaching case of interdisciplinary practical activities in junior high school and offers three suggestions for the future of interdisciplinary practical activities in chemistry to provide feasible teaching ideas and methods for interdisciplinary education practice.