With the inferior quality of the world crude, the heat transfer equipment in the hydrogenation reaction effluent air cooling (REAC) system is prone to flow corrosion problems which poses a serious threat to the production safety of the hydrogenation unit, such as dew point corrosion, salt deposition corrosion and erosion corrosion. In this paper, the flow-corrosion mechanism and evolution law of REAC system were analyzed, and the method of design, material selection and manufacture based on flow-corrosion check was introduced. Additionally, the flow-corrosion diagnosis and supervision model were constructed, and the flow-corrosion intelligent prevention and control platform of REAC system was developed. The platform can identify and diagnose the flow-corrosion risk of equipment according to the working conditions, and put forward corresponding prevention and control measures to provide effective guarantee for the safe production of enterprises.