In this paper, Al-Zn-In anode alloy is used as the primary tercomponent, and then the composition design is optimized through alloying and heat treatment. In terms of experiment, GB/T17848-1999 sacrificed-anode constant current experiment is carried out to test the open circuit potential, working potential, capacitance and current efficiency.At the same time, electrochemical tests such as polarization curve, electrochemical impedance spectroscopy, scanning Kelvin probe SKP (micro-region potential distribution measurement), metallographic structure observation and analysis were carried out for anode materials in high-temperature oil well produced liquid. Furthermore, virtual crystal approximation (VCA) was used to quantitatively design anode substrate composition. By calculating the anode work function and the adsorption energy of the main molecules and ions of the oil well produced liquid on the surface of the anode alloy, thje interfacial affinity between the alloy composition and the oil well produced liquid is predicted: the greater the affinity, the greater the tendency of dissolution reaction between the alloy interface and the produced liquid solution, and the better anode dissolution activity is expected. After optimization design, several new sacrificial anode samples were prepared, and comprehensive electrochemical protection performance tests were conducted. One sacrificial anode components was selected to meet the requirements of high-temperature and highly corrosive oil well environments.