The rapid increase in global population and climate change pose significant challenges to food security, demanding the development of resilient and high-yielding crops. Advances in genomics and gene editing technologies offer precise and efficient solutions for crop improvement. Given this, the chapter discusses cutting-edge gene editing tools, including CRISPR/Cas, TALENs, ZFNs, and meganucleases, with a focus on their applications in improving traits. Integrating genomic selection and genome-wide association studies with high-throughput phenotyping enables the identification of candidate genes associated with the target traits. Multi-omics approaches further facilitate deciphering the gene function and regulation, enabling targeted interventions for crop enhancement using genomics approaches. The combination of speed breeding with gene editing accelerates the development of superior cultivars within a short time frame. Additionally, innovations such as tissue culture-free genome editing and nanoparticle-mediated delivery systems offer practical solutions for diverse crops. Despite the transformative potential of gene editing, challenges related to off-target effects and gene editing accuracy remain, necessitating robust bioinformatics tools and precision-targeting strategies to circumvent these shortcomings. Altogether, the convergence of genomics and gene editing holds the potential for sustainable agriculture, facilitating the development of climate-resilient and nutritionally enhanced crop varieties that will help secure food and nutritional security for the ever-growing population.