Neurodegenerative diseases are characterized by degeneration of neurons, which is becoming more prevalent day by day, and the number of patients suffering from the neurodegenerative diseases also increases globally. The currently available treatment is only for the management of symptoms or the control of progression of disease. The new therapies come from natural products, synthesis, and existing drug; the therapies that come from existing drugs are drug repurposing and repositioning. Drug repurposing is a strategy of finding novel properties from well-known medications. This is more advantageous than other sources because it is reducing the time as well as cost and it is an alternative approach for the rapid development and identification of drugs for the diagnosis and treatment of rare and complex diseases. The cost required for the development of existing drugs is less than the development of new drug. There are several drug repurposing studies reported for finding out the new role of the existing drugs for the treatment of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis.