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Aldolase is a key glycolytic enzyme whose catalytic function facilitates the reversible splitting of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate, playing a vital role in cellular energy metabolism. Apart from this classical function, recent research points out the role in the process most important for the progression of cancer: epithelial–mesenchymal transition (EMT). EMT is one of the biological phenomena by which epithelial cells are converted into mesenchymal phenotypes, and thus drive metastasis of cancer and drug resistance. Aldolase contributes to EMT by regulating energy metabolism and interacting with signaling pathways such as Phosphoinositide 3-kinase (PI3K)/Protein kinase B (AKT) (PI3K/AKT) and Wnt/β-catenin, both being central to the regulation of EMT. Its non-catalytic roles, from contributions to cytoskeletal dynamics and transcriptional regulation, further underscore its role in EMT. Aldolase’s dual functions, in glycolysis and EMT, open avenues for understanding potential biomarkers and therapeutic targets in oncology. This chapter explores the molecular mechanisms linking aldolase to glycolysis and EMT in cancer progression.

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Aldolase Functions in Glycolysis and Epithelial–Mesenchymal Transition

  • 章节

  • 发表日期：

    2026年

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  • Kethavath Santhosh Nayak,
  • Kethavath Anjali Priya Naik,
  • Khawlhring Rosangzula,
  • Sangeetha Rathod,
  • Jarpala Saikrishna,
  • Ravinder Reddy Patlolla,
  • Sagar Narayan Tarate,
  • Polumati Anand,
  • Linga Banoth

摘要

Aldolase is a key glycolytic enzyme whose catalytic function facilitates the reversible splitting of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate, playing a vital role in cellular energy metabolism. Apart from this classical function, recent research points out the role in the process most important for the progression of cancer: epithelial–mesenchymal transition (EMT). EMT is one of the biological phenomena by which epithelial cells are converted into mesenchymal phenotypes, and thus drive metastasis of cancer and drug resistance. Aldolase contributes to EMT by regulating energy metabolism and interacting with signaling pathways such as Phosphoinositide 3-kinase (PI3K)/Protein kinase B (AKT) (PI3K/AKT) and Wnt/β-catenin, both being central to the regulation of EMT. Its non-catalytic roles, from contributions to cytoskeletal dynamics and transcriptional regulation, further underscore its role in EMT. Aldolase’s dual functions, in glycolysis and EMT, open avenues for understanding potential biomarkers and therapeutic targets in oncology. This chapter explores the molecular mechanisms linking aldolase to glycolysis and EMT in cancer progression.