This chapter examines the rapid rise of Asia as a significant global hub for startup activity and innovation. Over the last two decades, countries such as China, India, South Korea, and Singapore have become key players in the global entrepreneurial landscape, driven by urbanization, rising middle-class consumption, digital connectivity, open innovation strategies, and proactive government support. Several Asian cities now rank among the world’s top startup ecosystems. Despite these gains, challenges such as unequal infrastructure, regulatory hurdles, market fragmentation, and brain drain persist, especially in less developed economies. The chapter also highlights leading and emerging innovation hubs across Asia, providing a comparative analysis of ecosystem performance and international rankings.