This chapter advances Urbanimmunology by integrating comprehensive analyses of urban and social challenges with insights drawn from human immune intelligence, as discussed in previous chapters. It establishes the core principles of Urbanimmunology as a robust scientific paradigm, using these principles to guide the evolution of urban and social systems. The chapter introduces Kantor’s criteria—validity, significance, and comprehensiveness—as essential benchmarks for evaluating the scientific rigor of Urbanimmunology. It critically addresses the limitations of existing urban theories, highlighting their inadequacy in tackling the complex and dynamic nature of contemporary urban and social challenges. By synthesizing the strengths of these existing frameworks, the chapter refines Urbanimmunology to align with Kantor’s criteria, aiming to establish a more resilient theoretical foundation that balances practical applicability with epistemological depth. This integration of diverse theoretical perspectives forms the foundation of the chapter’s contribution to advancing Urbanimmunology.