Genetic testing has proven effective in health protection and targeted disease prevention, yet its adoption remains limited. Using data from the Health Information National Trends Survey (HINTS 6, N = 3,358), a nationally representative survey in the United States, this study employs hierarchical regression to examine the role of informational and communicative factors in influencing the adoption of genetic testing. The results indicate that individuals’ understanding of medical statistics, anxiety, exposure to genetic testing on the Internet, and interpersonal communication about genetic testing are positively associated with their adoption of genetic testing, whereas mass media exposure to genetic testing is negatively related to their adoption. Additionally, cancer risk perception was not found to be associated with genetic testing adoption. Notably, exposure to content on genetic testing on mass media moderated the effects of anxiety and risk perceptions (perceived susceptibility and severity) on the adoption of genetic testing.