The convergence of nanotechnology and omicsOmics technologiesTechnology has significantly advanced the development of plant-based functional foods by enhancing the identification, characterization, and bio efficacy of bioactive compounds. Plant-derived functional foods are recognized for their therapeutic potential in mitigating chronic conditions such as cardiovascular diseases, diabetes, and inflammation due to their abundance of phytochemicals, including polyphenols, flavonoids, and dietary fibers. Nevertheless, the clinical effectiveness of these compounds is often limited by factors such as poor solubility, low stability, and inadequate bioavailabilityBioavailability. OmicsOmics technologiesTechnology, comprising genomicsGenomics, transcriptomicsTranscriptomics, proteomicsProteomics, and metabolomicsMetabolomics, enable a systems-level understanding of the molecular mechanisms underpinning the bioactivity of functional compounds. The incorporation of nanotechnology enhances the application of omicsOmics by enabling improved encapsulation, targeted delivery, and controlled release of these compounds at the cellular level. This chapter explores the integrative role of nanotechnology in augmenting omicsOmics-based approaches within the functional food domain, emphasizing their combined utility in enhancing the nutritionalNutritional control and therapeutic quality of plant-based foods. A critical evaluation of current methodologies, functional food examples, health benefit pathways, limitations, and prospective advancements is presented. This interdisciplinary approach holds significant promise for the design of next generation, personalized functional foods that align with preventive and precision nutrition strategies.