Microgrippers serve as crucial end-effectors in micromanipulation systems, performing essential pick-transport-release tasks. This chapter details the development of a novel piezoelectrically actuated compliant microgripper, covering its design, modeling, optimization, simulation, and experimental validation. To address space and cost constraints, the design emphasizes high area-usage efficiency and optimal piezoelectric actuator utilization. A three-stage amplification mechanism–combining bridge-type and leverage configurations–enables large jaw displacements. Analytical methods, including pseudo-rigid-body modeling and response surface optimization, were used to refine the compliant structure. Finite-element analysis and physical prototyping validated performance, demonstrating a gripping displacement of 548.42 \(\upmu \) m, a natural frequency of 334 Hz, and a motion resolution of ±0.75 \(\upmu \) m. The microgripper outperforms prior designs in displacement, compactness, and actuation efficiency, successfully manipulating objects of varying sizes and shapes.