The operation of high-speed elevators produces a pronounced piston effect, leading to the formation of a complex unsteady flow field within the shaft. Piston wind pressure can cause the elevator door system panels to sway and increases noise, potentially impacting the performance of the door system. To investigate the impact of the piston effect on the door system, this paper creates a three-dimensional simplified model of both the elevator and the high-rise building and employs Computational Fluid Dynamics (CFD) to simulate the flow field generated at different operating speeds. The simulation results show the gas flow characteristics and pressure changes in various areas of high-rise building and near the elevator door system. Additionally, the piston wind pressure load on the elevator door during car operation is determined. Based on this, a mechanical model of the elevator door is established, and the finite element method is used to simulate and obtain three state parameters of the door system under different wind pressures: directional acceleration, equivalent stress, and total deformation. By simulating elevators operating at different speeds, the study elucidates the mechanism of piston wind effects on the door system and the variation patterns of the state parameters, thereby providing a theoretical foundation for performance analysis of high-speed elevator door systems affected by the piston effect.