Under the background of the K-12 “double new” reform (new curriculum, new textbook) issued by the Ministry of Education of the People’s Republic of China ( http://www.moe.gov.cn/fbh/live/2022/54639/sfcl/202207/t20220705_643405.html ), combined with modern education equipment, information technology and innovations in secondary school chemistry curriculum development, it is essential to explore how project-based teaching and learning methods can promote students’ core literacy and teachers’ experimental literacy. Based on this premise, the topic of “the automatic treatment of waste liquid in the secondary school chemistry laboratory” was selected. Resources such as TI calculators, digital sensors, and the Arduino open-source electronic prototype platform were integrated to design and explore project-based course activities, as well as practical research. On the one hand, this case is intended to provide a general teaching strategy with high universality, strong operability, replication, and promotion for the design and implementation of interdisciplinary project-based learning activities, on the other hand, it also intended to provide a reference for the global promotion of the deepening reform of primary and secondary school education and teaching oriented toward literacy.