This text discusses the micellar solubilization of poorly soluble particles in water. It introduces the concept of micellar solubilization using monocomponent micelles, applying the pseudophase model, which treats micelles as a macroscopic phase. Additionally, it addresses potential limitations of the pseudophase model in the thermodynamics of micellar solubilization, mainly due to the possible influence of Laplace capillary pressure. The text also explores using surfactant mixtures, precisely mixed micelles, to solubilize hard-to-dissolve particles in water. A thermodynamic model outlines the synergistic or antagonistic interactions between the different surfactants from their mixtures during the micellar solubilization relative to monocomponent micellar solubilization. Furthermore, the text delves into the thermodynamics of micellar co-solubilization, mainly when the poorly soluble phase in water consists of a multi-component system. It discusses how to characterize the interactions of various solubilizates in their mixture within the micellar pseudophase during the co-solubilization process.