Drug repurposing is a well-known technique in which already approved drugs are explored for alternate indications. It saves time and money which are involved in the drug development process. This technique is widely used to identify promising available drugs in the treatment of various diseases including COVID-19. This chapter offers a comprehensive exploration of the multifaceted approach in the management of COVID-19 patients through drug repurposing. This chapter starts with an overview of COVID-19 landscape, followed by the concept of drug repurposing, elucidating its significance as a swift and cost-effective method for identifying potential drug candidates. The discussion regarding repurposing candidates identified so far was also included along with their possible antiviral mechanisms. Furthermore, this chapter also highlights the transformative impact of innovative approaches such as network pharmacology, machine learning, artificial intelligence, and computational methods in the identification of repurposed drugs. Ultimately, this chapter serves as a valuable resource, offering both a comprehensive understanding of COVID-19 management through drug repurposing and an exploration of cutting-edge methodologies that hold promise in our ongoing battle against emerging infectious diseases.