With the increasing importance of computational thinking in education, especially in the information age, students must develop this core competency to address future challenges. In the latest version of Compulsory Education Curriculum Programme (2022 Edition), interdisciplinary thematic learning is identified as an explicit form of curriculum teaching, which provides an authentic and diversified practice scenario for the cultivation of computational thinking. Therefore, based on the analysis of the current situation, this study analyzes the feasibility of interdisciplinary thematic learning for computational thinking cultivation, introduced the 6E model into interdisciplinary thematic learning activities, and proposes a framework for the design of interdisciplinary thematic learning activities oriented to the cultivation of computational thinking. It is expected to provide a reference for frontline teachers to conduct cross-curricular thematic learning to develop computational thinking.