This chapter concentrates on politics of generative artificial intelligence in empowering higher education in the United States. The rapid development of generative artificial intelligence technology and the core technical functions it encompasses have drawn the attention of many countries around the world to the feasibility and inevitability of its integrated development with higher education. This study focuses its research perspective on the United States, which holds a leading position in the development of artificial intelligence worldwide. By meticulously reviewing the policy process of “generative artificial intelligence and higher education” in the United States and interpreting actual cases of applying generative artificial intelligence to higher education in American universities, we can comprehensively understand the current situation and actual progress of the integration and development of generative artificial intelligence and higher education in the United States, further reveal the challenges it faces in this field, and put forward corresponding suggestions. Research findings reveal that currently, the integrated development of generative artificial intelligence and higher education in the United States is confronted with significant challenges in terms of technological ethics, privacy security, technological adaptation, and resource allocation. In the future policy-making and implementation process, efforts should be focused on improving the policy system for generative artificial intelligence and higher education, establishing a committee on the ethics and morality of generative artificial intelligence, and strengthening the training and capacity building of generative artificial intelligence technology in the field of higher education to provide a foundation and conditions for the sustainable integrated development of generative artificial intelligence and higher education.