The integration of artificial intelligence into health care has the potential to revolutionize patient care by enhancing diagnostic accuracy, improving treatment plans, and optimizing health-care workflows. However, achieving these benefits requires seamless collaboration between artificial intelligence developers and health-care professionals. This chapter examines the foundation of the existing gaps between these groups, explores critical knowledge, and proposes strategies to foster effective interdisciplinary partnerships. By addressing these challenges, artificial intelligence solutions can be aligned with clinical needs, ensuring they are both user-friendly and impactful in improving health-care outcomes.