Secondary frequency regulation is essential for maintaining power system frequency stability, especially with the growing integration of renewable energy. The intermittent and unpredictable nature of renewable energy increases grid frequency fluctuations, while traditional thermal power units, limited by slow response times and high operating costs, struggle to meet the demands of rapid frequency changes. This paper proposes a comprehensive regulation strategy that combines the fast response capability of energy storage systems with the sustained adjustment capability of thermal power units. Simulation results show that this strategy significantly enhances frequency response speed, reduces recovery time, and minimizes steady-state frequency deviation. During the dynamic phase (0.8–1.2 s), the proposed strategy achieves a minimum frequency deviation of -0.07498 Hz, 9% lower than the Area Regulation Requirement and 15% lower than self-regulation, with a response time of 363.6 ms, demonstrating superior overall performance in both dynamic and steady-state phases.