The fabrication of deformable electronic and energy devices has transformed since the advent of nanotechtonics. In this chapter, the principles, material advancements, and fabrication techniques that have been applied to combine nanomaterials and tectonic design concepts for wearable, adaptable, and extensible systems are investigated. Advanced materials with specific mechanical and functional features, like metal-organic frameworks (MOFs), two-dimensional (2D) nanomaterials, and hybrid composites, are given particular attention. In addition, the chapter explores applications in wearable sensors, bio-integrated electronics, and next-generation energy storage, underlining the essential function that nanotechtonics plays in establishing the environment, performance, and adaptation.