The increasing prevalence of neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions has prompted extensive research into alternative therapeutic strategies, particularly the utilization of phytochemicals. This chapter summarizes key findings from both preclinical and clinical studies that illuminate the therapeutic potential of various phytochemicals in addressing neurological disorders. Preclinical evidence has consistently demonstrated that phytochemicals possess neuroprotective properties, functioning through multiple mechanisms including anti-oxidative, anti-inflammatory, and neurotrophin-enhancing effects. These studies highlight the potential of compounds such as curcumin, resveratrol, ginsenosides, and flavonoids in modulating neuroinflammation and promoting neuronal survival. The mechanisms through which these compounds exert their effects include the inhibition of neuroinflammation and modulation of neurotransmitter systems, thereby offering a multifaceted approach to managing neurological deficits. ​Moreover, clinical trials indicate that phytochemicals not only improve cognitive function but also mitigate symptoms associated with cognitive decline.​ Despite promising outcomes, challenges such as poor bioavailability and solubility of phytochemicals hinder their efficacy. Ongoing investigations into novel delivery systems, such as nanocarriers, show promise in enhancing the therapeutic viability of these compounds. Collectively, these studies underscore the critical need for further research to optimize the application of phytochemicals in clinical settings, driving forward the development of holistic approaches to effectively manage neurological disorders. In conclusion, the convergence of traditional knowledge and modern scientific inquiry into phytochemicals possesses the potential to revolutionize the management of neurological disorders, paving the way for more effective and holistic treatment approaches.