Radiant cooling system (RCS) has been an emerging air-conditioning method that has created a niche because of its primary energy saving and healthier indoor air characteristics. However, operating the RCS with renewable energy is rare due to necessity of compression chiller-based radiant system in the dedicated outdoor air system (DOAS). For including solar energy in the RCS, the presented work undertakes an EnergyPlus-based investigation to predict the electricity savings of vapor absorption chillers (VAC). Evaluations are compared with conventionally used design of the RCS, in which both radiant and DOAS units were functioned through compressor units. A triple-floor building layout amounting floor space of nearly 4,950 m2 is examined. Performance assessments were performed in relation to savings in grid-dependent electricity, load outlines, and sustained conditions described by zonal temperature and humidity, emissions, coefficient of performance (CoP) and allied metrics. Results portray that the VAC-based RCS saves nearly 28% of annual electricity and net emissions, as compared to the customary design. Temperature and relative humidity vary nearly between 20 ℃–26 ℃ and 36% - 55%, respectively. For the suggested design, annually-averaged CoP of the VAC and the DOAS chiller were obtained as 0.36 and 2.83, respectively.