This chapter highlights developmental and health conditions in children that could create challenges toward achieving their full potential and explores interventions that may promote their well-being and resilience. Children with or at risk for developmental disabilities, as well as hospitalized children and their families are confronted with a range of challenges that limit their full inclusion in daily routines. Creating opportunities for these vulnerable children and their families to overcome their challenges is within the scope of practice for human development professionals. Early intervention and pediatric psychosocial care services can mediate to serve as protective influences to promote child and family resilience. This chapter concludes with thought-provoking suggestions for new directions toward scaling up the role of human development professionals in providing early intervention services and pediatric psychosocial care services for children and families in India.