Uniportal full-endoscopic spine surgery is a highly advanced minimally invasive technique that provides exceptional flexibility in addressing various spinal pathologies with precision. Through the use of thin and elongated instruments, it facilitates targeted neural decompression while effectively preserving paraspinal muscles, stabilizing ligaments, and critical bony structures. This approach not only minimizes iatrogenic damage but also significantly reduces postoperative pain, accelerates recovery times, and allows for earlier patient mobilization and discharge. By minimizing surgical trauma and optimizing outcomes, uniportal full-endoscopic surgery has become a key advancement in modern spine surgery. This chapter examines the clinical advantages, technical aspects, and practical applications of this surgical approach.