Vitiligo is a chronic, acquired cutaneous disorder characterized by the loss of melanocytes, leading to depigmented skin and hair. It affects 0.1–2% of the population worldwide, without gender or racial predisposition. Childhood vitiligo, typically presenting before the age of 12 years, tends to be more progressive, with generalized and segmented subtypes being common. Childhood vitiligo is often associated with atopy and a positive family history. In contrast, late-onset vitiligo, which occurs after the age of 40 years, progresses more slowly and is more likely to be associated with autoimmune disorders. Treatment strategies differ by age, with early intervention crucial in children to prevent psychological distress, while adults also require the management of associated autoimmune disorders. This chapter discusses the epidemiology, clinical features, and management strategies for both childhood and late-onset vitiligo.