Tretinoin is an important topical retinoid used by dermatologists, currently approved by the FDA for the treatment of mild-to-moderate acne and photoaging. Besides, it is also used for a number of other indications, with propitious outcomes. Furthermore, tretinoin helps in normalizing differentiation of dysplastic epithelium and in this way shows promise as an adjuvant drug for cutaneous premalignant conditions. All these points make tretinoin an essential drug for dermatologic practice.