Research has shown that infrared radiation calibration technology is developing towards higher accuracy, stability, and real-time performance, providing necessary support for the widespread application of infrared technology. It is reasonable and feasible to use blackbody and infrared outer space methods for orbit all-optical path calibration of infrared space optical remote sensing cameras, with a focus on addressing issues such as blackbody working temperature uniformity, stability, and absolute radiation performance monitoring. By analyzing the factors affecting the calibration uncertainty of infrared remote sensors, we can effectively improve the radiation calibration accuracy by improving the onboard calibration scheme, providing onboard calibration blackbody temperature control accuracy, and combining infrared star calibration methods. The algorithm has been validated through ground laboratory testing. In response to the non-uniform changes caused by various factors in the in orbit space infrared remote sensor, the details of the in orbit absolute radiation calibration design scheme combining surface source blackbody calibration and stellar calibration were optimized. The temperature uniformity and stability control measures of blackbody were proposed, and the stellar extraction algorithm and data correction methods for stellar calibration and blackbody calibration were analyzed. Based on the specific development status of a certain remote sensor, we validated the algorithm based on laboratory test results and predicted the uncertainty of in orbit absolute radiation calibration. The application of infrared radiometric calibration technology in remote sensing, target recognition, and temperature measurement was also discussed, and its future development trends were discussed.